Effects of hydroxychloroquine on symptomatic improvement in primary Sjögren syndrome: the JOQUER randomized clinical trial.
Identifieur interne : 000349 ( Main/Exploration ); précédent : 000348; suivant : 000350Effects of hydroxychloroquine on symptomatic improvement in primary Sjögren syndrome: the JOQUER randomized clinical trial.
Auteurs : Jacques-Eric Gottenberg [France] ; Philippe Ravaud [France] ; Xavier Puéchal [France] ; Véronique Le Guern [France] ; Jean Sibilia [France] ; Vincent Goeb [France] ; Claire Larroche [France] ; Jean-Jacques Dubost [France] ; Stéphanie Rist [France] ; Alain Saraux [France] ; Valérie Devauchelle-Pensec [France] ; Jacques Morel [France] ; Gilles Hayem [France] ; Pierre Hatron [France] ; Aleth Perdriger [France] ; Damien Sene [France] ; Charles Zarnitsky [France] ; Djilali Batouche [France] ; Valérie Furlan [France] ; Joelle Benessiano [France] ; Elodie Perrodeau [France] ; Raphaele Seror [France] ; Xavier Mariette [France]Source :
- JAMA [ 1538-3598 ] ; 2014.
English descriptors
- KwdEn :
- Adult, Aged, Double-Blind Method, Enzyme Inhibitors (therapeutic use), Fatigue (drug therapy), Fatigue (etiology), Female, Humans, Hydroxychloroquine (therapeutic use), Male, Middle Aged, Pain (drug therapy), Pain (etiology), Sjogren's Syndrome (complications), Sjogren's Syndrome (drug therapy), Treatment Outcome.
- MESH :
- chemical , therapeutic use : Enzyme Inhibitors, Hydroxychloroquine.
- complications : Sjogren's Syndrome.
- drug therapy : Fatigue, Pain, Sjogren's Syndrome.
- etiology : Fatigue, Pain.
- Adult, Aged, Double-Blind Method, Female, Humans, Male, Middle Aged, Treatment Outcome.
Abstract
Primary Sjögren syndrome is a systemic autoimmune disease characterized by mouth and eye dryness, pain, and fatigue. Hydroxychloroquine is the most frequently prescribed immunosuppressant for the syndrome. However, evidence regarding its efficacy is limited.
DOI: 10.1001/jama.2014.7682
PubMed: 25027140
Affiliations:
- France
- Amiens, Bobigny, Brest, Clermont-Ferrand, Le Havre, Lille, Montpellier, Orléans, Paris, Rennes, Strasbourg
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Le document en format XML
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type="city">Brest</settlement></placeName></affiliation></author><author><name sortKey="Devauchelle Pensec, Valerie" sort="Devauchelle Pensec, Valerie" uniqKey="Devauchelle Pensec V" first="Valérie" last="Devauchelle-Pensec">Valérie Devauchelle-Pensec</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Brest University Hospital, Brest, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Brest University Hospital, Brest</wicri:regionArea><placeName><settlement type="city">Brest</settlement></placeName></affiliation></author><author><name sortKey="Morel, Jacques" sort="Morel, Jacques" uniqKey="Morel J" first="Jacques" last="Morel">Jacques Morel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Montpellier University Hospital, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Montpellier University 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Lille</wicri:regionArea><placeName><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Perdriger, Aleth" sort="Perdriger, Aleth" uniqKey="Perdriger A" first="Aleth" last="Perdriger">Aleth Perdriger</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Rennes University Hospital, Rennes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Rennes University Hospital, Rennes</wicri:regionArea><placeName><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Sene, Damien" sort="Sene, Damien" uniqKey="Sene D" first="Damien" last="Sene">Damien Sene</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Lariboisère Hospital, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Internal Medicine, Lariboisère Hospital, AP-HP, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Zarnitsky, Charles" sort="Zarnitsky, Charles" uniqKey="Zarnitsky C" first="Charles" last="Zarnitsky">Charles Zarnitsky</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Le Havre Hospital, Le Havre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Le Havre Hospital, Le Havre</wicri:regionArea><placeName><settlement type="city">Le Havre</settlement></placeName></affiliation></author><author><name sortKey="Batouche, Djilali" sort="Batouche, Djilali" uniqKey="Batouche D" first="Djilali" last="Batouche">Djilali Batouche</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hôpitaux Universitaires Paris-Sud, AP-HP, INSERM U 1012, Université Paris Sud, Le Kremlin Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Hôpitaux Universitaires Paris-Sud, AP-HP, INSERM U 1012, Université Paris Sud, Le Kremlin Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Furlan, Valerie" sort="Furlan, Valerie" uniqKey="Furlan V" first="Valérie" last="Furlan">Valérie Furlan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacy, Hôpitaux Universitaires Paris-Sud, AP-HP, Le Kremlin Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Pharmacy, Hôpitaux Universitaires Paris-Sud, AP-HP, Le Kremlin Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Benessiano, Joelle" sort="Benessiano, Joelle" uniqKey="Benessiano J" first="Joelle" 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type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Seror, Raphaele" sort="Seror, Raphaele" uniqKey="Seror R" first="Raphaele" last="Seror">Raphaele Seror</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hôpitaux Universitaires Paris-Sud, AP-HP, INSERM U 1012, Université Paris Sud, Le Kremlin Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Hôpitaux Universitaires Paris-Sud, AP-HP, INSERM U 1012, Université Paris Sud, Le Kremlin Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hôpitaux Universitaires Paris-Sud, AP-HP, INSERM U 1012, 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type="wicri:Area/Main/Curation">000349</idno><idno type="wicri:Area/Main/Exploration">000349</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Effects of hydroxychloroquine on symptomatic improvement in primary Sjögren syndrome: the JOQUER randomized clinical trial.</title><author><name sortKey="Gottenberg, Jacques Eric" sort="Gottenberg, Jacques Eric" uniqKey="Gottenberg J" first="Jacques-Eric" last="Gottenberg">Jacques-Eric Gottenberg</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Service de Rhumatologie, Hôpitaux Universitaires de Strasbourg, Centre de Référence National Pour les Maladies Auto-Immunes Systémiques Rares, Université de Strasbourg, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Service de Rhumatologie, Hôpitaux Universitaires de Strasbourg, Centre de Référence National Pour les Maladies Auto-Immunes Systémiques Rares, Université de Strasbourg, Strasbourg</wicri:regionArea><placeName><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Ravaud, Philippe" sort="Ravaud, Philippe" uniqKey="Ravaud P" first="Philippe" last="Ravaud">Philippe Ravaud</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Public Health, Hotel Dieu, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Epidemiology and Public Health, Hotel Dieu, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Puechal, Xavier" sort="Puechal, Xavier" uniqKey="Puechal X" first="Xavier" last="Puéchal">Xavier Puéchal</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Cochin Hospital, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Internal Medicine, Cochin Hospital, AP-HP, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Le Guern, Veronique" sort="Le Guern, Veronique" uniqKey="Le Guern V" first="Véronique" last="Le Guern">Véronique Le Guern</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Cochin Hospital, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Internal Medicine, Cochin Hospital, AP-HP, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Sibilia, Jean" sort="Sibilia, Jean" uniqKey="Sibilia J" first="Jean" last="Sibilia">Jean Sibilia</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Service de Rhumatologie, Hôpitaux Universitaires de Strasbourg, Centre de Référence National Pour les Maladies Auto-Immunes Systémiques Rares, Université de Strasbourg, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Service de Rhumatologie, Hôpitaux Universitaires de Strasbourg, Centre de Référence National Pour les Maladies Auto-Immunes Systémiques Rares, Université de Strasbourg, Strasbourg</wicri:regionArea><placeName><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Goeb, Vincent" sort="Goeb, Vincent" uniqKey="Goeb V" first="Vincent" last="Goeb">Vincent Goeb</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Amiens University Hospital, Amiens, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Amiens University Hospital, Amiens</wicri:regionArea><placeName><settlement type="city">Amiens</settlement></placeName></affiliation></author><author><name sortKey="Larroche, Claire" sort="Larroche, Claire" uniqKey="Larroche C" first="Claire" last="Larroche">Claire Larroche</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Avicenne Hospital, AP-HP, Bobigny, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Internal Medicine, Avicenne Hospital, AP-HP, Bobigny</wicri:regionArea><placeName><settlement type="city">Bobigny</settlement></placeName></affiliation></author><author><name sortKey="Dubost, Jean Jacques" sort="Dubost, Jean Jacques" uniqKey="Dubost J" first="Jean-Jacques" last="Dubost">Jean-Jacques Dubost</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Clermont-Ferrand University Hospital, Clermont-Ferrand, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Clermont-Ferrand University Hospital, Clermont-Ferrand</wicri:regionArea><placeName><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Rist, Stephanie" sort="Rist, Stephanie" uniqKey="Rist S" first="Stéphanie" last="Rist">Stéphanie Rist</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Orléans Hospital, Orléans, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Orléans Hospital, Orléans</wicri:regionArea><placeName><settlement type="city">Orléans</settlement></placeName></affiliation></author><author><name sortKey="Saraux, Alain" sort="Saraux, Alain" uniqKey="Saraux A" first="Alain" last="Saraux">Alain Saraux</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Brest University Hospital, Brest, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Brest University Hospital, Brest</wicri:regionArea><placeName><settlement type="city">Brest</settlement></placeName></affiliation></author><author><name sortKey="Devauchelle Pensec, Valerie" sort="Devauchelle Pensec, Valerie" uniqKey="Devauchelle Pensec V" first="Valérie" last="Devauchelle-Pensec">Valérie Devauchelle-Pensec</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Brest University Hospital, Brest, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Brest University Hospital, Brest</wicri:regionArea><placeName><settlement type="city">Brest</settlement></placeName></affiliation></author><author><name sortKey="Morel, Jacques" sort="Morel, Jacques" uniqKey="Morel J" first="Jacques" last="Morel">Jacques Morel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Montpellier University Hospital, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Montpellier University Hospital, Montpellier</wicri:regionArea><placeName><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Hayem, Gilles" sort="Hayem, Gilles" uniqKey="Hayem G" first="Gilles" last="Hayem">Gilles Hayem</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hôpital Bichat, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Hôpital Bichat, AP-HP, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Hatron, Pierre" sort="Hatron, Pierre" uniqKey="Hatron P" first="Pierre" last="Hatron">Pierre Hatron</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Lille University Hospital, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Internal Medicine, Lille University Hospital, Lille</wicri:regionArea><placeName><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Perdriger, Aleth" sort="Perdriger, Aleth" uniqKey="Perdriger A" first="Aleth" last="Perdriger">Aleth Perdriger</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Rennes University Hospital, Rennes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Rennes University Hospital, Rennes</wicri:regionArea><placeName><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Sene, Damien" sort="Sene, Damien" uniqKey="Sene D" first="Damien" last="Sene">Damien Sene</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Lariboisère Hospital, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Internal Medicine, Lariboisère Hospital, AP-HP, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Zarnitsky, Charles" sort="Zarnitsky, Charles" uniqKey="Zarnitsky C" first="Charles" last="Zarnitsky">Charles Zarnitsky</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Le Havre Hospital, Le Havre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Le Havre Hospital, Le Havre</wicri:regionArea><placeName><settlement type="city">Le Havre</settlement></placeName></affiliation></author><author><name sortKey="Batouche, Djilali" sort="Batouche, Djilali" uniqKey="Batouche D" first="Djilali" last="Batouche">Djilali Batouche</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hôpitaux Universitaires Paris-Sud, AP-HP, INSERM U 1012, Université Paris Sud, Le Kremlin Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Hôpitaux Universitaires Paris-Sud, AP-HP, INSERM U 1012, Université Paris Sud, Le Kremlin Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Furlan, Valerie" sort="Furlan, Valerie" uniqKey="Furlan V" first="Valérie" last="Furlan">Valérie Furlan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacy, Hôpitaux Universitaires Paris-Sud, AP-HP, Le Kremlin Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Pharmacy, Hôpitaux Universitaires Paris-Sud, AP-HP, Le Kremlin Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Benessiano, Joelle" sort="Benessiano, Joelle" uniqKey="Benessiano J" first="Joelle" last="Benessiano">Joelle Benessiano</name><affiliation wicri:level="1"><nlm:affiliation>Department of Centre de Ressources Biologiques, Bichat Hospital, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Centre de Ressources Biologiques, Bichat Hospital, AP-HP, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Perrodeau, Elodie" sort="Perrodeau, Elodie" uniqKey="Perrodeau E" first="Elodie" last="Perrodeau">Elodie Perrodeau</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Public Health, Hotel Dieu, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Epidemiology and Public Health, Hotel Dieu, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Seror, Raphaele" sort="Seror, Raphaele" uniqKey="Seror R" first="Raphaele" last="Seror">Raphaele Seror</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hôpitaux Universitaires Paris-Sud, AP-HP, INSERM U 1012, Université Paris Sud, Le Kremlin Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Hôpitaux Universitaires Paris-Sud, AP-HP, INSERM U 1012, Université Paris Sud, Le Kremlin Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rheumatology, Hôpitaux Universitaires Paris-Sud, AP-HP, INSERM U 1012, Université Paris Sud, Le Kremlin Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Rheumatology, Hôpitaux Universitaires Paris-Sud, AP-HP, INSERM U 1012, Université Paris Sud, Le Kremlin Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation></author></analytic><series><title level="j">JAMA</title><idno type="eISSN">1538-3598</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Double-Blind Method</term><term>Enzyme Inhibitors (therapeutic use)</term><term>Fatigue (drug therapy)</term><term>Fatigue (etiology)</term><term>Female</term><term>Humans</term><term>Hydroxychloroquine (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Pain (drug therapy)</term><term>Pain (etiology)</term><term>Sjogren's Syndrome (complications)</term><term>Sjogren's Syndrome (drug therapy)</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Enzyme Inhibitors</term><term>Hydroxychloroquine</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Sjogren's Syndrome</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Fatigue</term><term>Pain</term><term>Sjogren's Syndrome</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Fatigue</term><term>Pain</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Primary Sjögren syndrome is a systemic autoimmune disease characterized by mouth and eye dryness, pain, and fatigue. Hydroxychloroquine is the most frequently prescribed immunosuppressant for the syndrome. However, evidence regarding its efficacy is limited.</div></front></TEI><affiliations><list><country><li>France</li></country><settlement><li>Amiens</li><li>Bobigny</li><li>Brest</li><li>Clermont-Ferrand</li><li>Le Havre</li><li>Lille</li><li>Montpellier</li><li>Orléans</li><li>Paris</li><li>Rennes</li><li>Strasbourg</li></settlement></list><tree><country name="France"><noRegion><name sortKey="Gottenberg, Jacques Eric" sort="Gottenberg, Jacques Eric" uniqKey="Gottenberg J" first="Jacques-Eric" last="Gottenberg">Jacques-Eric Gottenberg</name></noRegion><name sortKey="Batouche, Djilali" sort="Batouche, Djilali" uniqKey="Batouche D" first="Djilali" last="Batouche">Djilali Batouche</name><name sortKey="Benessiano, Joelle" sort="Benessiano, Joelle" uniqKey="Benessiano J" first="Joelle" last="Benessiano">Joelle Benessiano</name><name sortKey="Devauchelle Pensec, Valerie" sort="Devauchelle Pensec, Valerie" uniqKey="Devauchelle Pensec V" first="Valérie" last="Devauchelle-Pensec">Valérie Devauchelle-Pensec</name><name sortKey="Dubost, Jean Jacques" sort="Dubost, Jean Jacques" uniqKey="Dubost J" first="Jean-Jacques" last="Dubost">Jean-Jacques Dubost</name><name sortKey="Furlan, Valerie" sort="Furlan, Valerie" uniqKey="Furlan V" first="Valérie" last="Furlan">Valérie Furlan</name><name sortKey="Goeb, Vincent" sort="Goeb, Vincent" uniqKey="Goeb V" first="Vincent" last="Goeb">Vincent Goeb</name><name sortKey="Hatron, Pierre" sort="Hatron, Pierre" uniqKey="Hatron P" first="Pierre" last="Hatron">Pierre Hatron</name><name sortKey="Hayem, Gilles" sort="Hayem, Gilles" uniqKey="Hayem G" first="Gilles" last="Hayem">Gilles Hayem</name><name sortKey="Larroche, Claire" sort="Larroche, Claire" uniqKey="Larroche C" first="Claire" last="Larroche">Claire Larroche</name><name sortKey="Le Guern, Veronique" sort="Le Guern, Veronique" uniqKey="Le Guern V" first="Véronique" last="Le Guern">Véronique Le Guern</name><name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name><name sortKey="Morel, Jacques" sort="Morel, Jacques" uniqKey="Morel J" first="Jacques" last="Morel">Jacques Morel</name><name sortKey="Perdriger, Aleth" sort="Perdriger, Aleth" uniqKey="Perdriger A" first="Aleth" last="Perdriger">Aleth Perdriger</name><name sortKey="Perrodeau, Elodie" sort="Perrodeau, Elodie" uniqKey="Perrodeau E" first="Elodie" last="Perrodeau">Elodie Perrodeau</name><name sortKey="Puechal, Xavier" sort="Puechal, Xavier" uniqKey="Puechal X" first="Xavier" last="Puéchal">Xavier Puéchal</name><name sortKey="Ravaud, Philippe" sort="Ravaud, Philippe" uniqKey="Ravaud P" first="Philippe" last="Ravaud">Philippe Ravaud</name><name sortKey="Rist, Stephanie" sort="Rist, Stephanie" uniqKey="Rist S" first="Stéphanie" last="Rist">Stéphanie Rist</name><name sortKey="Saraux, Alain" sort="Saraux, Alain" uniqKey="Saraux A" first="Alain" last="Saraux">Alain Saraux</name><name sortKey="Sene, Damien" sort="Sene, Damien" uniqKey="Sene D" first="Damien" last="Sene">Damien Sene</name><name sortKey="Seror, Raphaele" sort="Seror, Raphaele" uniqKey="Seror R" first="Raphaele" last="Seror">Raphaele Seror</name><name sortKey="Sibilia, Jean" sort="Sibilia, Jean" uniqKey="Sibilia J" first="Jean" last="Sibilia">Jean Sibilia</name><name sortKey="Zarnitsky, Charles" sort="Zarnitsky, Charles" uniqKey="Zarnitsky C" first="Charles" last="Zarnitsky">Charles Zarnitsky</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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